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High-accuracy modeling of antibody structures by a search for minimum-energy recombination of backbone fragments

Current methods for antibody structure prediction rely on sequence homology to known structures. Although this strategy often yields accurate predictions, models can be stereo-chemically strained. Here, we present a fully automated algorithm, called AbPredict, that disregards sequence homology, and...

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Detalhes bibliográficos
Publicado no:Proteins
Main Authors: Norn, Christoffer H., Lapidoth, Gideon, Fleishman, Sarel J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432028/
https://ncbi.nlm.nih.gov/pubmed/27717001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25185
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