Principles for computational design of binding antibodies

Natural proteins must both fold into a stable conformation and exert their molecular function. To date, computational design has successfully produced stable and atomically accurate proteins by using so-called “ideal” folds rich in regular secondary structures and almost devoid of loops and destabil...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Baran, Dror, Pszolla, M. Gabriele, Lapidoth, Gideon D., Norn, Christoffer, Dym, Orly, Unger, Tamar, Albeck, Shira, Tyka, Michael D., Fleishman, Sarel J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642698/
https://ncbi.nlm.nih.gov/pubmed/28973872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707171114
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