Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces

Antibodies developed for research and clinical applications may exhibit suboptimal stability, expressibility, or affinity. Existing optimization strategies focus on surface mutations, whereas natural affinity maturation also introduces mutations in the antibody core, simultaneously improving stabili...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Warszawski, Shira, Borenstein Katz, Aliza, Lipsh, Rosalie, Khmelnitsky, Lev, Ben Nissan, Gili, Javitt, Gabriel, Dym, Orly, Unger, Tamar, Knop, Orli, Albeck, Shira, Diskin, Ron, Fass, Deborah, Sharon, Michal, Fleishman, Sarel J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728052/
https://ncbi.nlm.nih.gov/pubmed/31442220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007207
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