Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces

Antibodies developed for research and clinical applications may exhibit suboptimal stability, expressibility, or affinity. Existing optimization strategies focus on surface mutations, whereas natural affinity maturation also introduces mutations in the antibody core, simultaneously improving stabili...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:PLoS Comput Biol
Autors principals: Warszawski, Shira, Borenstein Katz, Aliza, Lipsh, Rosalie, Khmelnitsky, Lev, Ben Nissan, Gili, Javitt, Gabriel, Dym, Orly, Unger, Tamar, Knop, Orli, Albeck, Shira, Diskin, Ron, Fass, Deborah, Sharon, Michal, Fleishman, Sarel J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728052/
https://ncbi.nlm.nih.gov/pubmed/31442220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007207
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars