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Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces
Antibodies developed for research and clinical applications may exhibit suboptimal stability, expressibility, or affinity. Existing optimization strategies focus on surface mutations, whereas natural affinity maturation also introduces mutations in the antibody core, simultaneously improving stabili...
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| 出版年: | PLoS Comput Biol |
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| 主要な著者: | , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6728052/ https://ncbi.nlm.nih.gov/pubmed/31442220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007207 |
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