Automated design of efficient and functionally diverse enzyme repertoires

Substantial improvements in enzyme activity demand multiple mutations at spatially proximal positions in the active site. Such mutations, however, often exhibit unpredictable epistatic (non-additive) effects on activity. Here, we describe FuncLib - an automated method for designing multipoint mutati...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Khersonsky, Olga, Lipsh, Rosalie, Avizemer, Ziv, Ashani, Yacov, Goldsmith, Moshe, Leader, Haim, Dym, Orly, Rogotner, Shelly, Trudeau, Devin L., Prilusky, Jaime, Amengual-Rigo, Pep, Guallar, Victor, Tawfik, Dan S., Fleishman, Sarel J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193528/
https://ncbi.nlm.nih.gov/pubmed/30270109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.033
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