Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability

Upon heterologous overexpression, many proteins misfold or aggregate, thus resulting in low functional yields. Human acetylcholinesterase (hAChE), an enzyme mediating synaptic transmission, is a typical case of a human protein that necessitates mammalian systems to obtain functional expression. We d...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Goldenzweig, Adi, Goldsmith, Moshe, Hill, Shannon E., Gertman, Or, Laurino, Paola, Ashani, Yacov, Dym, Orly, Unger, Tamar, Albeck, Shira, Prilusky, Jaime, Lieberman, Raquel L., Aharoni, Amir, Silman, Israel, Sussman, Joel L., Tawfik, Dan S., Fleishman, Sarel J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
Assuntos:
Technology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961223/
https://ncbi.nlm.nih.gov/pubmed/27425410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.06.012
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