Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function

Antizyme inhibitor (AzI) regulates cellular polyamine homeostasis by binding to the polyamine-induced protein, Antizyme (Az), with greater affinity than ornithine decarboxylase (ODC). AzI is highly homologous to ODC but is not enzymatically active. In order to understand these specific characteristi...

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Bibliographic Details
Main Authors: Albeck, Shira, Dym, Orly, Unger, Tamar, Snapir, Zohar, Bercovich, Zippy, Kahana, Chaim
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2327289/
https://ncbi.nlm.nih.gov/pubmed/18369191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073427208
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