Automated design of efficient and functionally diverse enzyme repertoires

Substantial improvements in enzyme activity demand multiple mutations at spatially proximal positions in the active site. Such mutations, however, often exhibit unpredictable epistatic (non-additive) effects on activity. Here, we describe FuncLib - an automated method for designing multipoint mutati...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Mol Cell
Autors principals: Khersonsky, Olga, Lipsh, Rosalie, Avizemer, Ziv, Ashani, Yacov, Goldsmith, Moshe, Leader, Haim, Dym, Orly, Rogotner, Shelly, Trudeau, Devin L., Prilusky, Jaime, Amengual-Rigo, Pep, Guallar, Victor, Tawfik, Dan S., Fleishman, Sarel J.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193528/
https://ncbi.nlm.nih.gov/pubmed/30270109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.033
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars