A de novo protein binding pair by computational design and directed evolution

The de novo design of protein-protein interfaces is a stringent test of our understanding of the principles underlying protein-protein interactions and would enable new approaches to biological and medical challenges. Here we describe a novel motif-based method to computationally design protein-prot...

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Detalhes bibliográficos
Main Authors: Karanicolas, John, Corn, Jacob E., Chen, Irwin, Joachimiak, Lukasz A., Dym, Orly, Peck, Sun H., Albeck, Shira, Unger, Tamar, Hu, Wenxin, Liu, Gaohua, Delbecq, Scott, Montelione, Gaetano, Spiegel, Clint, Liu, David R., Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102007/
https://ncbi.nlm.nih.gov/pubmed/21458342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.03.010
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