A de novo protein binding pair by computational design and directed evolution

The de novo design of protein-protein interfaces is a stringent test of our understanding of the principles underlying protein-protein interactions and would enable new approaches to biological and medical challenges. Here we describe a novel motif-based method to computationally design protein-prot...

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Autors principals: Karanicolas, John, Corn, Jacob E., Chen, Irwin, Joachimiak, Lukasz A., Dym, Orly, Peck, Sun H., Albeck, Shira, Unger, Tamar, Hu, Wenxin, Liu, Gaohua, Delbecq, Scott, Montelione, Gaetano, Spiegel, Clint, Liu, David R., Baker, David
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102007/
https://ncbi.nlm.nih.gov/pubmed/21458342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.03.010
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