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Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir

Conflicting drug-drug interaction (DDI) studies with the HIV protease inhibitors (PIs) suggest net induction or inhibition of intestinal or hepatic CYP3A. As part of a larger DDI study in healthy volunteers, we determined the effect of extended administration of two PIs, ritonavir (RTV) or nelfinavi...

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Autors principals: Kirby, Brian J., Collier, Ann C., Kharasch, Evan D., Whittington, Dale, Thummel, Kenneth E., Unadkat, Jashvant D.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100903/
https://ncbi.nlm.nih.gov/pubmed/21406602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.037523
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