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As in Humans, Pregnancy Increases the Clearance of the Protease Inhibitor Nelfinavir in the Nonhuman Primate Macaca nemestrina

The apparent oral clearance of protease inhibitors (PIs) is increased in pregnant women. Although this phenomenon is reproduced in the mouse, because of the multiplicity of mouse cytochrome P450 isoforms, lack of information on their substrate and inhibitor selectivity, and lack of reagents (e.g., a...

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Bibliografski detalji
Glavni autori: Zhang, Huixia, Wu, Xiaohui, Chung, Francisco, Naraharisetti, Suresh Babu, Whittington, Dale, Mirfazaelian, Ahmad, Unadkat, Jashvant D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Pharmacology and Experimental Therapeutics 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683778/
https://ncbi.nlm.nih.gov/pubmed/19293388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.151746
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