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As in Humans, Pregnancy Increases the Clearance of the Protease Inhibitor Nelfinavir in the Nonhuman Primate Macaca nemestrina

The apparent oral clearance of protease inhibitors (PIs) is increased in pregnant women. Although this phenomenon is reproduced in the mouse, because of the multiplicity of mouse cytochrome P450 isoforms, lack of information on their substrate and inhibitor selectivity, and lack of reagents (e.g., a...

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Detalles Bibliográficos
Main Authors: Zhang, Huixia, Wu, Xiaohui, Chung, Francisco, Naraharisetti, Suresh Babu, Whittington, Dale, Mirfazaelian, Ahmad, Unadkat, Jashvant D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Pharmacology and Experimental Therapeutics 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683778/
https://ncbi.nlm.nih.gov/pubmed/19293388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.151746
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