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Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo
Ritonavir, an HIV protease inhibitor, is successfully used for the prevention and treatment of HIV infections. Ritonavir pharmacokinetics are complicated by inhibition, induction and pharmacogenetics of cytochrome P450 (CYP) enzymes mediating its clearance. This investigation revealed that CYP2J2, a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4169885/ https://ncbi.nlm.nih.gov/pubmed/24973543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.06.020 |
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