Pharmacokinetic–pharmacodynamic relationships of central nervous system effects of scopolamine in healthy subjects

AIM(S): Although scopolamine is a frequently used memory impairment model, the relationships between exposure and corresponding central nervous system (CNS) effects are mostly unknown. The aim of our study was to characterize these using pharmacokinetic–pharmacodynamic (PK–PD) modelling. METHODS: In...

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Main Authors: Liem-Moolenaar, Marieke, de Boer, Peter, Timmers, Maarten, Schoemaker, Rik C, van Hasselt, J G Coen, Schmidt, Stephan, van Gerven, Joop M A
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2011
Fag:
Pharmacokinetic Dynamic Relationships
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099375/
https://ncbi.nlm.nih.gov/pubmed/21306419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.03936.x
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