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Pharmacokinetic–pharmacodynamic relationships of central nervous system effects of scopolamine in healthy subjects

AIM(S): Although scopolamine is a frequently used memory impairment model, the relationships between exposure and corresponding central nervous system (CNS) effects are mostly unknown. The aim of our study was to characterize these using pharmacokinetic–pharmacodynamic (PK–PD) modelling. METHODS: In...

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Main Authors: Liem-Moolenaar, Marieke, de Boer, Peter, Timmers, Maarten, Schoemaker, Rik C, van Hasselt, J G Coen, Schmidt, Stephan, van Gerven, Joop M A
פורמט: Artigo
שפה:Inglês
יצא לאור: Blackwell Science Inc 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099375/
https://ncbi.nlm.nih.gov/pubmed/21306419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.03936.x
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