Model‐based exposure‐response analysis to quantify age related differences in the response to scopolamine in healthy subjects

AIM: Subjects with increasing age are more sensitive to the effects of the anti‐muscarinic agent scopolamine, which is used (among other indications) to induce temporary cognitive dysfunction in early phase drug studies with cognition enhancing compounds. The enhanced sensitivity has always been att...

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Udgivet i:Br J Clin Pharmacol
Main Authors: Alvarez‐Jimenez, Ricardo, Groeneveld, Geert Jan, van Gerven, Joop M. A., Goulooze, Sebastiaan C., Baakman, Anne Catrien, Hay, Justin L., Stevens, Jasper
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Pharmacokinetic Dynamic Relationships
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137826/
https://ncbi.nlm.nih.gov/pubmed/27273555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13031
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