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Model‐based exposure‐response analysis to quantify age related differences in the response to scopolamine in healthy subjects
AIM: Subjects with increasing age are more sensitive to the effects of the anti‐muscarinic agent scopolamine, which is used (among other indications) to induce temporary cognitive dysfunction in early phase drug studies with cognition enhancing compounds. The enhanced sensitivity has always been att...
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| Publicado no: | Br J Clin Pharmacol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5137826/ https://ncbi.nlm.nih.gov/pubmed/27273555 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13031 |
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