An anti‐nicotinic cognitive challenge model using mecamylamine in comparison with the anti‐muscarinic cognitive challenge using scopolamine

AIMS: The muscarinic acetylcholine receptor antagonist scopolamine is often used for proof‐of‐pharmacology studies with pro‐cognitive compounds. From a pharmacological point of view, it would seem more rational to use a nicotinic rather than a muscarinic anticholinergic challenge to prove pharmacolo...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Baakman, Anne Catrien, Alvarez‐Jimenez, Ricardo, Rissmann, Robert, Klaassen, Erica S., Stevens, Jasper, Goulooze, Sebastiaan C., den Burger, Jeroen C. G., Swart, Eleonora L., van Gerven, Joop M. A., Groeneveld, Geert Jan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510063/
https://ncbi.nlm.nih.gov/pubmed/28217868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13268
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