An anti‐nicotinic cognitive challenge model using mecamylamine in comparison with the anti‐muscarinic cognitive challenge using scopolamine

AIMS: The muscarinic acetylcholine receptor antagonist scopolamine is often used for proof‐of‐pharmacology studies with pro‐cognitive compounds. From a pharmacological point of view, it would seem more rational to use a nicotinic rather than a muscarinic anticholinergic challenge to prove pharmacolo...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Baakman, Anne Catrien, Alvarez‐Jimenez, Ricardo, Rissmann, Robert, Klaassen, Erica S., Stevens, Jasper, Goulooze, Sebastiaan C., den Burger, Jeroen C. G., Swart, Eleonora L., van Gerven, Joop M. A., Groeneveld, Geert Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Pharmacokinetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510063/
https://ncbi.nlm.nih.gov/pubmed/28217868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13268
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