Pharmacokinetic–pharmacodynamic relationships of central nervous system effects of scopolamine in healthy subjects

AIM(S): Although scopolamine is a frequently used memory impairment model, the relationships between exposure and corresponding central nervous system (CNS) effects are mostly unknown. The aim of our study was to characterize these using pharmacokinetic–pharmacodynamic (PK–PD) modelling. METHODS: In...

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Detalhes bibliográficos
Main Authors: Liem-Moolenaar, Marieke, de Boer, Peter, Timmers, Maarten, Schoemaker, Rik C, van Hasselt, J G Coen, Schmidt, Stephan, van Gerven, Joop M A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2011
Assuntos:
Pharmacokinetic Dynamic Relationships
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099375/
https://ncbi.nlm.nih.gov/pubmed/21306419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.03936.x
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