Pharmacokinetic–pharmacodynamic relationships of central nervous system effects of scopolamine in healthy subjects

AIM(S): Although scopolamine is a frequently used memory impairment model, the relationships between exposure and corresponding central nervous system (CNS) effects are mostly unknown. The aim of our study was to characterize these using pharmacokinetic–pharmacodynamic (PK–PD) modelling. METHODS: In...

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Bibliografiset tiedot
Päätekijät: Liem-Moolenaar, Marieke, de Boer, Peter, Timmers, Maarten, Schoemaker, Rik C, van Hasselt, J G Coen, Schmidt, Stephan, van Gerven, Joop M A
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Blackwell Science Inc 2011
Aiheet:
Pharmacokinetic Dynamic Relationships
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099375/
https://ncbi.nlm.nih.gov/pubmed/21306419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.03936.x
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