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Design and Synthesis of Truncated 4′-Thioadenosine Derivatives as Potent and Selective A(3) Adenosine Receptor Antagonists
We have established structure-activity relationships of novel truncated D-4′-thioadenosine derivatives from d-mannose as potent and selective A(3) adenosine receptor (AR) antagonists. At the human A(3) AR, most of N(6)-substituted analogues showed high potency and selectivity and acted as pure antag...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3097420/ https://ncbi.nlm.nih.gov/pubmed/18776543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nass/nrn324 |
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