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Design and Synthesis of Truncated 4′-Thioadenosine Derivatives as Potent and Selective A(3) Adenosine Receptor Antagonists

We have established structure-activity relationships of novel truncated D-4′-thioadenosine derivatives from d-mannose as potent and selective A(3) adenosine receptor (AR) antagonists. At the human A(3) AR, most of N(6)-substituted analogues showed high potency and selectivity and acted as pure antag...

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Bibliografische gegevens
Hoofdauteurs: Hou, Xiyan, Pal, Shantanu, Choi, Won Jun, Kim, Hea Ok, Tipnis, Amol, Jacobson, Kenneth A., Jeong, Lak Shin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3097420/
https://ncbi.nlm.nih.gov/pubmed/18776543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nass/nrn324
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