Characterization of an altered DNA catalysis of a camptothecin-resistant eukaryotic topoisomerase I.

We investigated topoisomerase I activity at a specific camptothecin-enhanced cleavage site by use of a partly double-stranded DNA substrate. The cleavage site belongs to a group of DNA topoisomerase I sites which is only efficiently cleaved by wild-type topoisomerase I (topo I-wt) in the presence of...

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Main Authors: Gromova, I I, Kjeldsen, E, Svejstrup, J Q, Alsner, J, Christiansen, K, Westergaard, O
Format: Artigo
Jezik:Inglês
Izdano: 1993
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC309157/
https://ncbi.nlm.nih.gov/pubmed/8382801
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