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Characterization of DNA Topoisomerase-1 in Spodoptera exigua for Toxicity Evaluation of Camptothecin and Hydoxy-Camptothecin

Camptothecin (CPT), a plant alkaloid originally isolated from the native Chinese tree, Camptotheca acuminate, exerts the toxic effect by targeting eukaryotic DNA topoisomerase 1 (DNA Topo1). Besides as potent anti-cancer agents, CPT and its derivatives are now being explored as potential pesticides...

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Bibliografiske detaljer
Main Authors: Zhang, Lan, Ma, Dejun, Zhang, Yanning, He, Weizhi, Yang, Jingjing, Li, Chuanren, Jiang, Hongyun
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579855/
https://ncbi.nlm.nih.gov/pubmed/23451051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056458
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