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Characterization of an altered DNA catalysis of a camptothecin-resistant eukaryotic topoisomerase I.
We investigated topoisomerase I activity at a specific camptothecin-enhanced cleavage site by use of a partly double-stranded DNA substrate. The cleavage site belongs to a group of DNA topoisomerase I sites which is only efficiently cleaved by wild-type topoisomerase I (topo I-wt) in the presence of...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
1993
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| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC309157/ https://ncbi.nlm.nih.gov/pubmed/8382801 |
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