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Characterization of an altered DNA catalysis of a camptothecin-resistant eukaryotic topoisomerase I.
We investigated topoisomerase I activity at a specific camptothecin-enhanced cleavage site by use of a partly double-stranded DNA substrate. The cleavage site belongs to a group of DNA topoisomerase I sites which is only efficiently cleaved by wild-type topoisomerase I (topo I-wt) in the presence of...
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| Publicado en: | Nucleic Acids Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
1993
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| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309157/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8382801/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.3.593 |
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