Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.
DNA topoisomerase I was purified to near homogeneity from a clonal line of human lymphoblastic leukemia cells, RPMI 8402, that is resistant to camptothecin, a cytotoxic alkaloid from Camptotheca acuminata, and compared with that of the parent wild-type cells. As assayed by relaxation of the supercoi...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1987
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298903/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3039492/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.16.5565 |
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