Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

DNA topoisomerase I was purified to near homogeneity from a clonal line of human lymphoblastic leukemia cells, RPMI 8402, that is resistant to camptothecin, a cytotoxic alkaloid from Camptotheca acuminata, and compared with that of the parent wild-type cells. As assayed by relaxation of the supercoi...

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Autors principals: Andoh, T, Ishii, K, Suzuki, Y, Ikegami, Y, Kusunoki, Y, Takemoto, Y, Okada, K
Format: Artigo
Idioma:Inglês
Publicat: 1987
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC298903/
https://ncbi.nlm.nih.gov/pubmed/3039492
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