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Sequence dependent modulating effect of camptothecin on the DNA-cleaving activity of the calf thymus type I topoisomerase.

High-resolution mapping of topol cleavages in the regions of human DNA including the oncogene c-Ha-ras and p53, has revealed three kinds of topol cleavage sites: cleavage sites not affected by camptothecin; cleavage sites reinforced only in the presence of camptothecin, and cleavage sites which weak...

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Detalhes bibliográficos
Main Authors: Gromova, I I, Buchman, V L, Abagyan, R A, Ulyanov, A V, Bronstein, I B
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC333473/
https://ncbi.nlm.nih.gov/pubmed/2155407
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