In vivo sequencing of camptothecin-induced topoisomerase I cleavage sites in human colon carcinoma cells.

Camptothecin (CPT) is a specific topoisomerase I (top1) poison which traps top1 cleavable complexes; e.g. top1-linked DNA single-strand breaks with 5'-hydroxyl and 3'-top1 linked termini. CPT is also a potent anticancer agent and several of its derivatives have recently shown activity in the chemoth...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Pondarré, C, Strumberg, D, Fujimori, A, Torres-León, R, Pommier, Y
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147024/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9321666/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.20.4111
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