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In vivo sequencing of camptothecin-induced topoisomerase I cleavage sites in human colon carcinoma cells.

Camptothecin (CPT) is a specific topoisomerase I (top1) poison which traps top1 cleavable complexes; e.g. top1-linked DNA single-strand breaks with 5'-hydroxyl and 3'-top1 linked termini. CPT is also a potent anticancer agent and several of its derivatives have recently shown activity in t...

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Detaylı Bibliyografya
Asıl Yazarlar: Pondarré, C, Strumberg, D, Fujimori, A, Torres-León, R, Pommier, Y
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1997
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC147024/
https://ncbi.nlm.nih.gov/pubmed/9321666
Etiketler: Etiketle
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