In vivo sequencing of camptothecin-induced topoisomerase I cleavage sites in human colon carcinoma cells.
Camptothecin (CPT) is a specific topoisomerase I (top1) poison which traps top1 cleavable complexes; e.g. top1-linked DNA single-strand breaks with 5'-hydroxyl and 3'-top1 linked termini. CPT is also a potent anticancer agent and several of its derivatives have recently shown activity in the chemoth...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Nucleic Acids Res |
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| Prif Awduron: | , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Oxford University Press
1997
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147024/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9321666/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.20.4111 |
| Tagiau: |
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