Spatial organization of topoisomerase I-mediated DNA cleavage induced by camptothecin–oligonucleotide conjugates

Triple helix-forming oligonucleotides covalently linked to topoisomerase I inhibitors, in particular the antitumor agent camptothecin, trigger topoisomerase I-mediated DNA cleavage selectively in the proximity of the binding site of the oligonucleotide vector. In the present study, we have performed...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Arimondo, Paola B., Angenault, Stéphane, Halby, Ludovic, Boutorine, Alexandre, Schmidt, Frédéric, Monneret, Claude, Garestier, Thérèse, Sun, Jian-Sheng, Bailly, Christian, Hélène, Claude
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2003
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165972/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12853620/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg457
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