Spatial organization of topoisomerase I-mediated DNA cleavage induced by camptothecin–oligonucleotide conjugates

Triple helix-forming oligonucleotides covalently linked to topoisomerase I inhibitors, in particular the antitumor agent camptothecin, trigger topoisomerase I-mediated DNA cleavage selectively in the proximity of the binding site of the oligonucleotide vector. In the present study, we have performed...

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Main Authors: Arimondo, Paola B., Angenault, Stéphane, Halby, Ludovic, Boutorine, Alexandre, Schmidt, Frédéric, Monneret, Claude, Garestier, Thérèse, Sun, Jian-Sheng, Bailly, Christian, Hélène, Claude
Format: Artigo
Language:Inglês
Published: Oxford University Press 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC165972/
https://ncbi.nlm.nih.gov/pubmed/12853620
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