Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

DNA topoisomerase I was purified to near homogeneity from a clonal line of human lymphoblastic leukemia cells, RPMI 8402, that is resistant to camptothecin, a cytotoxic alkaloid from Camptotheca acuminata, and compared with that of the parent wild-type cells. As assayed by relaxation of the supercoi...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Andoh, T, Ishii, K, Suzuki, Y, Ikegami, Y, Kusunoki, Y, Takemoto, Y, Okada, K
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1987
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298903/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3039492/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.16.5565
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