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The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.
The eukaryotic topoisomerase I (topo I) is the target of the cytotoxic alkaloid camptothecin (CTT). In vitro, CTT enhances the breakage of DNA by topo I when the reaction is stopped with detergent. Although breakage at some sites is enhanced to a great extent while breakage at others is enhanced onl...
Shranjeno v:
| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
1989
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC335024/ https://ncbi.nlm.nih.gov/pubmed/2555774 |
| Oznake: |
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