The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.
The eukaryotic topoisomerase I (topo I) is the target of the cytotoxic alkaloid camptothecin (CTT). In vitro, CTT enhances the breakage of DNA by topo I when the reaction is stopped with detergent. Although breakage at some sites is enhanced to a great extent while breakage at others is enhanced onl...
Uloženo v:
| Vydáno v: | Nucleic Acids Res |
|---|---|
| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
1989
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| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC335024/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2555774/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/17.21.8521 |
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