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The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.

The eukaryotic topoisomerase I (topo I) is the target of the cytotoxic alkaloid camptothecin (CTT). In vitro, CTT enhances the breakage of DNA by topo I when the reaction is stopped with detergent. Although breakage at some sites is enhanced to a great extent while breakage at others is enhanced onl...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Porter, S E, Champoux, J J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 1989
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC335024/
https://ncbi.nlm.nih.gov/pubmed/2555774
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