Ligand-Dependent Disorder of the Ω Loop Observed in Extended-Spectrum SHV-Type β-Lactamase

Among Gram-negative bacteria, resistance to β-lactams is mediated primarily by β-lactamases (EC 3.2.6.5), periplasmic enzymes that inactivate β-lactam antibiotics. Substitutions at critical amino acid positions in the class A β-lactamase families result in enzymes that can hydrolyze extended-spectru...

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Autores principales: Sampson, Jared M., Ke, Wei, Bethel, Christopher R., Pagadala, S. R. R., Nottingham, Michael D., Bonomo, Robert A., Buynak, John D., van den Akker, Focco
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2011
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088229/
https://ncbi.nlm.nih.gov/pubmed/21357298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01360-10
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