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Why the Extended-Spectrum β-Lactamases (ESBLs) SHV-2 and SHV-5 are “Hyper-Susceptible” to Mechanism-Based Inhibitors
Extended-spectrum β-lactamases (ESBLs) are derivatives of enzymes such as SHV-1 and TEM-1 that have undergone site-specific mutations that enable them to hydrolyze, and thus inactivate, oxyimino-cephalosporins, such as cefotaxime and ceftazidime. X-ray crystallographic data provide an explanation fo...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2770726/ https://ncbi.nlm.nih.gov/pubmed/19736945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9012098 |
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