Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide

Human ACE (angiotensin-I-converting enzyme) has long been regarded as an excellent target for the treatment of hypertension and related cardiovascular diseases. Highly potent inhibitors have been developed and are extensively used in the clinic. To develop inhibitors with higher therapeutic efficacy...

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Detalhes bibliográficos
Main Authors: Akif, Mohd, Schwager, Sylva L., Anthony, Colin S., Czarny, Bertrand, Beau, Fabrice, Dive, Vincent, Sturrock, Edward D., Acharya, K. Ravi
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086271/
https://ncbi.nlm.nih.gov/pubmed/21352096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20102123
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