Interkingdom Pharmacology of Angiotensin-I Converting Enzyme Inhibitor Phosphonates Produced by Actinomycetes

[Image: see text] The K-26 family of bacterial secondary metabolites are N-modified tripeptides terminated by an unusual phosphonate analog of tyrosine. These natural products, produced via three different actinomycetales, are potent inhibitors of human angiotensin-I converting enzyme (ACE). Herein...

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Main Authors: Kramer, Glenna J., Mohd, Akif, Schwager, Sylva L. U., Masuyer, Geoffrey, Acharya, K. Ravi, Sturrock, Edward D., Bachmann, Brian O.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2014
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027624/
https://ncbi.nlm.nih.gov/pubmed/24900839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4004588
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