The N Domain of Human Angiotensin-I-converting Enzyme: THE ROLE OF N-GLYCOSYLATION AND THE CRYSTAL STRUCTURE IN COMPLEX WITH AN N DOMAIN-SPECIFIC PHOSPHINIC INHIBITOR, RXP407

Angiotensin-I-converting enzyme (ACE) plays a critical role in the regulation of blood pressure through its central role in the renin-angiotensin and kallikrein-kinin systems. ACE contains two domains, the N and C domains, both of which are heavily glycosylated. Structural studies of ACE have been f...

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Detalhes bibliográficos
Main Authors: Anthony, Colin S., Corradi, Hazel R., Schwager, Sylva L. U., Redelinghuys, Pierre, Georgiadis, Dimitris, Dive, Vincent, Acharya, K. Ravi, Sturrock, Edward D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975193/
https://ncbi.nlm.nih.gov/pubmed/20826823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167866
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