The N domain of somatic angiotensin-converting enzyme negatively regulates ectodomain shedding and catalytic activity

sACE (somatic angiotensin-converting enzyme) consists of two homologous, N and C domains, whereas the testis isoenzyme [tACE (testis ACE)] consists of a single C domain. Both isoenzymes are shed from the cell surface by a sheddase activity, although sACE is shed much less efficiently than tACE. We h...

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Autors principals: Woodman, Zenda L., Schwager, Sylva L. U., Redelinghuys, Pierre, Carmona, Adriana K., Ehlers, Mario R. W., Sturrock, Edward D.
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2005
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1180724/
https://ncbi.nlm.nih.gov/pubmed/15813703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050187
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