Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

Angiotensin-converting enzyme 2 (ACE2) is a terminal carboxypeptidase and the receptor for the SARS and NL63 coronaviruses (CoV). Loss of ACE2 function is implicated in severe acute respiratory syndrome (SARS) pathogenesis, but little is known about ACE2 biogenesis and activity in the airways. We re...

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Hauptverfasser: Jia, Hong Peng, Look, Dwight C., Tan, Ping, Shi, Lei, Hickey, Melissa, Gakhar, Lokesh, Chappell, Mark C., Wohlford-Lenane, Christine, McCray, Paul B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2009
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711803/
https://ncbi.nlm.nih.gov/pubmed/19411314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00071.2009
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