Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

Dementia with Lewy bodies (DLB) and Parkinson's Disease (PD) are common causes of motor and cognitive deficits and are associated with the abnormal accumulation of alpha-synuclein (α-syn). This study investigated whether passive immunization with a novel monoclonal α-syn antibody (9E4) against...

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Detaylı Bibliyografya
Asıl Yazarlar: Masliah, Eliezer, Rockenstein, Edward, Mante, Michael, Crews, Leslie, Spencer, Brian, Adame, Anthony, Patrick, Christina, Trejo, Margarita, Ubhi, Kiren, Rohn, Troy T., Mueller-Steiner, Sarah, Seubert, Peter, Barbour, Robin, McConlogue, Lisa, Buttini, Manuel, Games, Dora, Schenk, Dale
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084838/
https://ncbi.nlm.nih.gov/pubmed/21559417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019338
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