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Crystal structure of a covalent intermediate in DNA cleavage and rejoining by Escherichia coli DNA topoisomerase I

DNA topoisomerases control DNA topology by breaking and rejoining DNA strands via covalent complexes with cleaved DNA substrate as catalytic intermediates. Here we report the structure of Escherichia coli topoisomerase I catalytic domain (residues 2–695) in covalent complex with a cleaved single-str...

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Bibliografiske detaljer
Main Authors: Zhang, Zhongtao, Cheng, Bokun, Tse-Dinh, Yuk-Ching
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084087/
https://ncbi.nlm.nih.gov/pubmed/21482796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100300108
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