Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I

Escherichia coli topoisomerase I has an essential function in preventing hypernegative supercoiling of DNA. A full length structure of E. coli topoisomerase I reported here shows how the C-terminal domains bind single-stranded DNA (ssDNA) to recognize the accumulation of negative supercoils in duple...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Tan, Kemin, Zhou, Qingxuan, Cheng, Bokun, Zhang, Zhongtao, Joachimiak, Andrzej, Tse-Dinh, Yuk-Ching
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678816/
https://ncbi.nlm.nih.gov/pubmed/26490962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1073
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