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Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I
Escherichia coli topoisomerase I has an essential function in preventing hypernegative supercoiling of DNA. A full length structure of E. coli topoisomerase I reported here shows how the C-terminal domains bind single-stranded DNA (ssDNA) to recognize the accumulation of negative supercoils in duple...
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| Publicado en: | Nucleic Acids Res |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4678816/ https://ncbi.nlm.nih.gov/pubmed/26490962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1073 |
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