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Experimental and computational investigations of Ser10 and Lys13 in the binding and cleavage of DNA substrates by Escherichia coli DNA topoisomerase I

Ser10 and Lys13 found near the active site tyrosine of Escherichia coli DNA topoisomerase I are conserved among the type IA topoisomerases. Site-directed mutagenesis of these two residues to Ala reduced the relaxation and DNA cleavage activity, with a more severe effect from the Lys13 mutation. Chan...

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Bibliografische gegevens
Hoofdauteurs: Strahs, Daniel, Zhu, Chang-Xi, Cheng, Bokun, Chen, Jason, Tse-Dinh, Yuk-Ching
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2006
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1421505/
https://ncbi.nlm.nih.gov/pubmed/16582104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl109
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