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BACTERIAL CELL KILLING MEDIATED BY TOPOISOMERASE I DNA CLEAVAGE ACTIVITY

DNA topoisomerases are important clinical targets for antibacterial and anticancer therapy. At least one type IA DNA topoisomerases can be found in every bacterium, making it a logical target for antibacterial agents that can convert the enzyme into poison by trapping its covalent complex with DNA....

詳細記述

保存先:
書誌詳細
主要な著者: Cheng, Bokun, Shukla, Shikha, Vasunilashorn, Sarinnapha, Mukhopadhyay, Somshuvra, Tse-Dinh, Yuk-Ching
フォーマット: Artigo
言語:Inglês
出版事項: 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1351368/
https://ncbi.nlm.nih.gov/pubmed/16159875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M509722200
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